human YWHAE shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human YWHAE.
shAAV-228002
AAV-h-YWHAE-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human YWHAE (tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
14-3-3E; HEL2; KCIP-1; MDCR; MDS
Description (Vector)
YWHAE product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 100% identical to the mouse ortholog. It interacts with CDC25 phosphatases, RAF1 and IRS1 proteins, suggesting its role in diverse biochemical activities related to signal transduction, such as cell division and regulation of insulin sensitivity. It has also been implicated in the pathogenesis of small cell lung cancer. Two transcript variants, one protein-coding and the other non-protein-coding, have been found for this gene.
Gene ID
7531
Gene Name (Vector)
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon
Gene Symbol
YWHAE
HGNC ID
HGNC:12851
ORF Size (aa)
768
RefSeq ID
NM_006761
RefSeq Synonyms
NM_006761, BC001440, BC000179,
Species
human
UniGene ID
Hs.513851
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.