human YBX1 shRNA silencing AAV

Name 
AAV-h-YBX1-shRNA
Cat No 
shAAV-227950
Availability
4-5 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human YBX1.

shAAV-227950
AAV-h-YBX1-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human YBX1 (Y-box binding protein 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
90
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
BP-8; CBF-A; CCAAT-binding transcription factor I subunit A; CSDA2; CSDB; DBPB; DNA-binding protein B; EFI-A; enhancer factor I subunit A; major histocompatibility complex, class II, Y box-binding protein I; MDR-NF1; NSEP1; NSEP-1; nuclease-sensitive element-binding protein 1; YB1; YB-1; Y-box transcription factor; Y-box-binding protein 1
Description (eCommerce)
Y-box-binding protein 1 (YB1) Regulates the transcription of numerous genes. It has been shown to promote separation of DNA strands that contain mismatches or are modified by cisplatin, and shown to have endonucleolytic activity that can introduce nicks or breaks into double-stranded DNA (in vitro). YB1 may play a role in DNA repair. It is a component of the CRD-mediated complex that promotes MYC mRNA stability [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/ P67809].
Gene ID
4904
Gene Name (eCommerce)
Y-box binding protein 1
Gene Name (Vector)
Y-box binding protein 1
Gene Symbol
YBX1
HGNC ID
HGNC:8014
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
975
ORF Size (bp)
975 bp
Protein Name (eCommerce)
Nuclease-sensitive element-binding protein 1
RefSeq ID
NM_004559
RefSeq Synonyms
NM_004559, BC106045, BC098435, BC090038, BC071708, BC070084, BC065571, BC038384, BC015208, BC010430, BC002411,
Research Areas
BDNF Signaling,Gene Expression,Interleukin Signaling,mRNA Processing,mRNA Splicing,Neurobiology,RNA Binding,RNA Processing,Signal Transduction,Spliceosome,Transcription Factor/Regulator
Research Areas (Faceted)
signal_transduction,immunology,genetics,transcription_translation,immunology,genetics,neurobiology,cell_biology,genetics,transcription_translation
Species
human
Target Sentence
Y-box-binding protein 1 (YB1) Regulates the transcription of numerous genes. It has been shown to promote separation of DNA strands that contain mismatches or are modified by cisplatin, and shown to have endonucleolytic activity that can introduce nicks or breaks into double-stranded DNA (in vitro). YB1 may play a role in DNA repair. It is a component of the CRD-mediated complex that promotes MYC mRNA stability [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/ P67809].
UniGene ID
Hs.473583
UniProt ID (eCommerce)
P67809

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About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.