human XRN1 shRNA silencing AAV

Name 
AAV-h-XRN1-shRNA
Cat No 
shAAV-227937
Availability
4-5 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human XRN1.

shAAV-227937
AAV-h-XRN1-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human XRN1 (5′-3′ exoribonuclease 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
80
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
5'-3' exoribonuclease 1; SEP1; strand-exchange protein 1 homolog
Description (eCommerce)
5’-3’ exoribonuclease 1 (XRN1) is a ribonuclease localized in the cytoplasm that functions in mRNA metabolism and is found in messenger ribonucleoprotein (mRNP) complexes. The mouse and yeast homologs of XRN1 are Dhm2 and SEP1 respectively. In a glial cell line, XRN1 is induced by glial cell line–derived growth factor (GDNF) and associates with microtubules. XRN1 has also been identified as a candidate tumor suppressor gene in osteogenic sarcoma.
Description (Vector)
SEP1 localizes to cytoplasmic foci containing a complex of mRNA-degrading enzymes. In addition to mRNA metabolism, yeast Sep1 has been implicated in a variety of nuclear and cytoplasmic functions, including homologous recombination, meiosis, telomere maintenance, and microtubule assembly.(supplied by OMIM, Apr 2004)
Gene ID
54464
Gene Name (eCommerce)
5'-3' exoribonuclease 1
Gene Name (Vector)
5'-3' exoribonuclease 1
Gene Symbol
XRN1
HGNC ID
HGNC:30654
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
5118
ORF Size (bp)
5118 bp
Protein Name (eCommerce)
5'-3' exoribonuclease 1
RefSeq ID
NM_019001
RefSeq Synonyms
NM_019001, NM_001282859, NM_001282857, NM_001042604, BC141555,
Research Areas
Cancer,Cell Cycle,Cytoskeleton,Gene Expression,Golgi Apparatus,mRNA Binding,RNA Binding,RNA Processing,Telomeric Maintenance,Tumor Suppressors/Oncoproteins
Research Areas (Faceted)
cancer,cell_biology,cell_cycle,genetics,transcription_translation,cell_biology,genetics,cancer
Species
human
Target Sentence
5’-3’ exoribonuclease 1 (XRN1) is a ribonuclease localized in the cytoplasm that functions in mRNA metabolism and is found in messenger ribonucleoprotein (mRNP) complexes. The mouse and yeast homologs of XRN1 are Dhm2 and SEP1 respectively. In a glial cell line, XRN1 is induced by glial cell line–derived growth factor (GDNF) and associates with microtubules. XRN1 has also been identified as a candidate tumor suppressor gene in osteogenic sarcoma.
UniGene ID
Hs.435103
UniProt ID (eCommerce)
Q8IZH2

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.