human XRCC4 shRNA silencing AAV

Name
AAV-h-XRCC4-shRNA

Cat No
shAAV-227926

Availability
4-5 weeks

This is an AAV expressing shRNA for silencing of Human XRCC4.

shAAV-227926

AAV-h-XRCC4-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human XRCC4 (X-ray repair cross complementing 4). Available with optional GFP reporter or cell-specific promoter.

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Vector Designer

Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

SSMED

Description (Vector)

XRCC4 functions together with DNA ligase IV and the DNA-dependent protein kinase in the repair of DNA double-strand break by non-homologous end joining and the completion of V(D)J recombination events. The non-homologous end-joining pathway is required both for normal development and for suppression of tumors. This gene functionally complements XR-1 Chinese hamster ovary cell mutant, which is impaired in DNA double-strand breaks produced by ionizing radiation and restriction enzymes. Alternative transcription initiation and alternative splicing generates several transcript variants.

Gene ID

7518

Gene Name (Vector)

X-ray repair cross complementing 4

Gene Symbol

XRCC4

HGNC ID

HGNC:12831

ORF Size (aa)

933

RefSeq ID

NM_022406

RefSeq Synonyms

NM_022550, NM_022406, NM_003401, NM_001318013, NM_001318012, BC016314, BC005259,

Species

human

UniGene ID

Hs.567359

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.