human XIAP shRNA silencing AAV

Name
AAV-h-XIAP-shRNA

Cat No
shAAV-227883

Availability
4-5 weeks

This is an AAV expressing shRNA for silencing of Human XIAP.

shAAV-227883

AAV-h-XIAP-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human XIAP (X-linked inhibitor of apoptosis). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

API3; BIRC4; hIAP-3; hIAP3; IAP-3; ILP1; MIHA; XLP2

Description (Vector)

XIAP encodes a protein that belongs to a family of apoptotic suppressor proteins. Members of this family share a conserved motif termed, baculovirus IAP repeat, which is necessary for their anti-apoptotic function. This protein functions through binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2 and inhibits apoptosis induced by menadione, a potent inducer of free radicals, and interleukin 1-beta converting enzyme. This protein also inhibits at least two members of the caspase family of cell-death proteases, caspase-3 and caspase-7. Mutations in this gene are the cause of X-linked lymphoproliferative syndrome. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 2 and 11.

Gene ID

331

Gene Name (Vector)

X-linked inhibitor of apoptosis

Gene Symbol

XIAP

HGNC ID

HGNC:592

ORF Size (aa)

1494

ORF Size (bp)

1494 bp

RefSeq ID

NM_001167

RefSeq Synonyms

NM_001204401, NM_001167, BC032729,

Species

human

UniGene ID

Hs.356076

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.