human WFS1 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human WFS1.
shAAV-227779
AAV-h-WFS1-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human WFS1 (wolframin ER transmembrane glycoprotein). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
CTRCT41; WFRS; WFS; WFSL
Description (Vector)
WFS1 encodes a transmembrane protein, which is located primarily in the endoplasmic reticulum and ubiquitously expressed with highest levels in brain, pancreas, heart, and insulinoma beta-cell lines. Mutations in this gene are associated with Wolfram syndrome, also called DIDMOAD (Diabetes Insipidus, Diabetes Mellitus, Optic Atrophy, and Deafness), an autosomal recessive disorder. The disease affects the brain and central nervous system. Mutations in this gene can also cause autosomal dominant deafness 6 (DFNA6), also known as DFNA14 or DFNA38. Alternatively spliced transcript variants have been found for this gene.
Gene ID
7466
Gene Name (Vector)
wolframin ER transmembrane glycoprotein
Gene Symbol
WFS1
HGNC ID
HGNC:12762
ORF Size (aa)
2673
ORF Size (bp)
2673 bp
RefSeq ID
NM_006005
RefSeq Synonyms
NM_006005, NM_001145853, BC030130,
Species
human
UniGene ID
Hs.716556
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.