human WDR45 shRNA silencing AAV

Name
AAV-h-WDR45-shRNA

Cat No
shAAV-227683

Availability
4-5 weeks

This is an AAV expressing shRNA for silencing of Human WDR45.

shAAV-227683

AAV-h-WDR45-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human WDR45 (WD repeat domain 45). Available with optional GFP reporter or cell-specific promoter.

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Vector Designer

Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

JM5; NBIA4; NBIA5; WDRX1; WIPI-4; WIPI4

Description (Vector)

WDR45 encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. WDR45 has a pseudogene at chromosome 4q31.3. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene, but the biological validity and full-length nature of some variants have not been determined.

Gene ID

11152

Gene Name (Vector)

WD repeat domain 45

Gene Symbol

WDR45

HGNC ID

HGNC:28912

ORF Size (aa)

1083

RefSeq ID

NM_007075

RefSeq Synonyms

NM_007075, NM_001029896, BC069206, BC003037, BC000464,

Species

human

UniGene ID

Hs.632807

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.