human WBP11 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human WBP11.
shAAV-227607
AAV-h-WBP11-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human WBP11 (WW domain binding protein 11). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
Npw38-binding protein; Npw38-binding protein NpwBP; NPWBP; PPP1R165; protein phosphatase 1, regulatory subunit 165; SH3 domain-binding protein SNP70; SIPP1; splicing factor that interacts with PQBP-1 and PP1; splicing factor, PQBP1 and PP1 interacting; WBP-11; WW domain-binding protein 11
Description (eCommerce)
WW domain-binding protein 11 (WBP11) activates pre-mRNA splicing. It may inhibit PP1 phosphatase activity [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q9Y2W2].
Description (Vector)
WBP11 encodes a nuclear protein, which colocalizes with mRNA splicing factors and intermediate filament-containing perinuclear networks. This protein has 95% amino acid sequence identity to the mouse Wbp11 protein. It contains two proline-rich regions that bind to the WW domain of Npw38, a nuclear protein, and thus this protein is also called Npw38-binding protein NpwBP. The Npw38-NpwBP complex may function as a component of an mRNA factory in the nucleus.
Gene ID
51729
Gene Name (eCommerce)
WW domain binding protein 11
Gene Name (Vector)
WW domain binding protein 11
Gene Symbol
WBP11
HGNC ID
HGNC:16461
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1926
ORF Size (bp)
1926 bp
Protein Name (eCommerce)
WW domain-binding protein 11
RefSeq ID
NM_016312
RefSeq Synonyms
NM_016312, BC023532, BC001621,
Research Areas
Gene Expression,Kinase/Phosphatase,mRNA Processing,mRNA Splicing,RNA Processing
Research Areas (Faceted)
cell_biology,genetics,signal_transduction,transcription_translation
Species
human
Target Sentence
WW domain-binding protein 11 (WBP11) activates pre-mRNA splicing. It may inhibit PP1 phosphatase activity [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q9Y2W2].
UniGene ID
Hs.655138
UniProt ID (eCommerce)
Q9Y2W2
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.