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human VPS18 shRNA silencing AAV

Name 
AAV-h-VPS18-shRNA
Cat No 
shAAV-227514
Availability
6-8 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human VPS18.

shAAV-227514
AAV-h-VPS18-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human VPS18 (VPS18, CORVET/HOPS core subunit). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
hVPS18; PEP3; vacuolar protein sorting 18 homolog; vacuolar protein sorting protein 18; vacuolar protein sorting-associated protein 18 homolog
Description (eCommerce)
Vesicle mediated protein sorting plays an important role in segregation of intracellular molecules into distinct organelles. Genetic studies in yeast have identified more than 40 vacuolar protein sorting (VPS) genes involved in vesicle transport to vacuoles. VPS18 is the human homolog of yeast class C Vps18 protein. The mammalian class C Vps proteins are predominantly associated with late endosomes/lysosomes, and like their yeast counterparts, may mediate vesicle trafficking steps in the endosome/lysosome pathway [taken from NCBI Entrez Gene (Gene ID: 57617)].
Description (Vector)
Vesicle mediated protein sorting plays an important role in segregation of intracellular molecules into distinct organelles. Genetic studies in yeast have identified more than 40 vacuolar protein sorting (VPS) genes involved in vesicle transport to vacuoles. This gene encodes the human homolog of yeast class C Vps18 protein. The mammalian class C Vps proteins are predominantly associated with late endosomes/lysosomes, and like their yeast counterparts, may mediate vesicle trafficking steps in the endosome/lysosome pathway.
Gene ID
57617
Gene Name (eCommerce)
VPS18, CORVET/HOPS core subunit
Gene Name (Vector)
VPS18, CORVET/HOPS core subunit
Gene Symbol
VPS18
HGNC ID
HGNC:15972
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1743
ORF Size (bp)
1743 bp
Protein Name (eCommerce)
Vacuolar protein sorting-associated protein 18 homolog
RefSeq ID
NM_020857
RefSeq Synonyms
NM_020857, BC001513,
Research Areas
Lysosome,Zinc-finger
Research Areas (Faceted)
cell_biology
Species
human
Target Sentence
Vesicle mediated protein sorting plays an important role in segregation of intracellular molecules into distinct organelles. Genetic studies in yeast have identified more than 40 vacuolar protein sorting (VPS) genes involved in vesicle transport to vacuoles. VPS18 is the human homolog of yeast class C Vps18 protein. The mammalian class C Vps proteins are predominantly associated with late endosomes/lysosomes, and like their yeast counterparts, may mediate vesicle trafficking steps in the endosome/lysosome pathway [taken from NCBI Entrez Gene (Gene ID: 57617)].
UniGene ID
Hs.23876
UniProt ID (eCommerce)
Q9P253

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.