human VBP1 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human VBP1.
shAAV-227421
AAV-h-VBP1-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human VBP1 (VHL binding protein 1). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
HIBBJ46; PFD3; PFDN3; prefoldin subunit 3; VBP-1; VHL-binding protein 1; von Hippel-Lindau binding protein 1; von Hippel-Lindau-binding protein 1
Description (eCommerce)
Von Hippel-Lindau-binding protein 1 (VBP1) binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. VPB1 binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/P61758].
Description (Vector)
VBP1 interacts with the Von Hippel-Lindau protein to form an intracellular complex. Because it functions as a chaperone protein, it is suspected that it may play a role in the transport of the Von Hippel-Lindau protein from the perinuclear granules to the nucleus or cytoplasm.
Gene ID
7411
Gene Name (eCommerce)
VHL binding protein 1
Gene Name (Vector)
VHL binding protein 1
Gene Symbol
VBP1
HGNC ID
HGNC:12662
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
594
Protein Name (eCommerce)
Prefoldin subunit 3
RefSeq ID
NM_003372
RefSeq Synonyms
NM_003372, NM_001303545, NM_001303544, NM_001303543, BC046094,
Research Areas
Metabolism/Metabolic Process,Protein Folding,Translational Control
Research Areas (Faceted)
cell_biology,metabolism,transcription_translation
Species
human
Target Sentence
Von Hippel-Lindau-binding protein 1 (VBP1) binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. VPB1 binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/P61758].
UniGene ID
Hs.436803
UniProt ID (eCommerce)
P61758
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.