human USP39 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human USP39.
shAAV-227319
AAV-h-USP39-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human USP39 (ubiquitin specific peptidase 39). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
65K; CGI-21; HSPC332; inactive ubiquitin-specific peptidase 39; SAD1; SAD1 homolog; small nuclear ribonucleoprotein 65kDa (U4/U6.U5); SnRNP assembly defective 1 homolog; SNRNP65; U4/U6.U5 tri-snRNP-associated 65 kDa protein; U4/U6.U5 tri-snRNP-associated protein 2; ubiquitin specific protease 39
Description (eCommerce)
USP39 plays a role in pre-mRNA splicing as a component of the U4/U6-U5 tri-snRNP, one of the building blocks of the spliceosome. USP39 regulates AURKB mRNA levels, and thereby plays a role in cytokinesis and in the spindle checkpoint. USP39 does not have ubiquitin-specific peptidase activity, but could be a competitor of ubiquitin C-terminal hydrolases (UCHs)Â [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q53GS9].
Gene ID
10713
Gene Name (eCommerce)
ubiquitin specific peptidase 39
Gene Name (Vector)
ubiquitin specific peptidase 39
Gene Symbol
USP39
HGNC ID
HGNC:20071
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1698
ORF Size (bp)
1698 bp
Protein Name (eCommerce)
U4/U6.U5 tri-snRNP-associated protein 2
RefSeq ID
NM_006590
RefSeq Synonyms
NM_006590, NM_001256728, NM_001256727, NM_001256726, NM_001256725, BC067273,
Research Areas
Cell Cycle,Cell Division,Gene Expression,mRNA Processing,mRNA Splicing,RNA Processing,Spliceosome,Zinc-finger
Research Areas (Faceted)
cell_biology,cell_cycle,genetics,transcription_translation
Species
human
Target Sentence
USP39 plays a role in pre-mRNA splicing as a component of the U4/U6-U5 tri-snRNP, one of the building blocks of the spliceosome. USP39 regulates AURKB mRNA levels, and thereby plays a role in cytokinesis and in the spindle checkpoint. USP39 does not have ubiquitin-specific peptidase activity, but could be a competitor of ubiquitin C-terminal hydrolases (UCHs)Â [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q53GS9].
UniGene ID
Hs.654745
UniProt ID (eCommerce)
Q53GS9
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.