human USP33 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human USP33.
shAAV-227309
AAV-h-USP33-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human USP33 (ubiquitin specific peptidase 33). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
deubiquitinating enzyme 33; hVDU1; pVHL-interacting deubiquitinating enzyme 1; ubiquitin carboxyl-terminal hydrolase 33; ubiquitin thioesterase 33; ubiquitin thiolesterase 33; ubiquitin-specific-processing protease 33; VDU1; VHL-interacting deubiquitinating enzyme 1
Description (eCommerce)
Ubiquitin (Ub) is a highly conserved protein found ubiquitously in eukaryotic organisms. The conjugation of ubiquitin to proteins is an important means to regulate protein activity for many cellular processes by tagging them for degradation. Removal of Ub can rescue proteins from degradation. This is accomplished by the ubiquitin-specific processing protease (UBP) family of enzymes. Ubiquitin specific processing protease 33 (USP33) is a member of this family.
Description (Vector)
USP33 encodes a deubiquinating enzyme important in a variety of processes, including Slit-dependent cell migration and beta-2 adrenergic receptor signaling. The protein is negatively regulated through ubiquitination by von Hippel-Lindau tumor protein (VHL). Alternative splicing results in multiple transcript variants and protein isoforms.
Gene ID
23032
Gene Name (eCommerce)
ubiquitin specific peptidase 33
Gene Name (Vector)
ubiquitin specific peptidase 33
Gene Symbol
USP33
HGNC ID
HGNC:20059
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2487
ORF Size (bp)
2487 bp
Protein Name (eCommerce)
Ubiquitin carboxyl-terminal hydrolase 33
RefSeq ID
NM_015017
RefSeq Synonyms
NM_201626, NM_201624, NM_015017, BC016663,
Research Areas
Axon Guidance,Cytoskeleton,Golgi Apparatus,Neurobiology,Ubiquitination,Zinc-finger
Research Areas (Faceted)
cell_biology,neurobiology
Species
human
Target Sentence
Ubiquitin (Ub) is a highly conserved protein found ubiquitously in eukaryotic organisms. The conjugation of ubiquitin to proteins is an important means to regulate protein activity for many cellular processes by tagging them for degradation. Removal of Ub can rescue proteins from degradation. This is accomplished by the ubiquitin-specific processing protease (UBP) family of enzymes. Ubiquitin specific processing protease 33 (USP33) is a member of this family.
UniGene ID
Hs.480597
UniProt ID (eCommerce)
Q8TEY7
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.