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human UBXN1 shRNA silencing AAV

Name 
AAV-h-UBXN1-shRNA
Cat No 
shAAV-227087
Availability
6-8 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human UBXN1.

shAAV-227087
AAV-h-UBXN1-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human UBXN1 (UBX domain protein 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
2B28; SAKS1; SAPK substrate protein 1; UBA/UBX 33.3 kDa protein; UBX domain-containing protein 1; UBXD10
Description (eCommerce)
UBX domain-containing protein 1 (UBXN1) is a ubiquitin-binding protein that interacts with the BRCA1-BARD1 heterodimer, and regulates its activity. Specifically binds 'Lys-6'-linked polyubiquitin chains. The interaction between UBXN1 and autoubiquitinated BRCA1, leads to the inhibition the E3 ubiquitin-protein ligase activity of the BRCA1-BARD1 heterodimer. UBXN1 is also a component of a complex required to couple deglycosylation and proteasome-mediated degradation of misfolded proteins in the endoplasmic reticulum that are retrotranslocated in the cytosol.3 kDa protein, UBXD10, 2B28, and SAKS1.
Gene ID
51035
Gene Name (eCommerce)
UBX domain protein 1
Gene Name (Vector)
UBX domain protein 1
Gene Symbol
UBXN1
HGNC ID
HGNC:18402
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
894
ORF Size (bp)
894 bp
Protein Name (eCommerce)
UBX domain-containing protein 1
RefSeq ID
NM_015853
RefSeq Synonyms
NM_015853, NM_001286078, NM_001286077, BC040129, BC001372, BC000902,
Research Areas
Complexome,Neurobiology,Proteasome,Ubiquitination
Research Areas (Faceted)
cell_biology,neurobiology
Species
human
Target Sentence
UBX domain-containing protein 1 (UBXN1) is a ubiquitin-binding protein that interacts with the BRCA1-BARD1 heterodimer, and regulates its activity. Specifically binds 'Lys-6'-linked polyubiquitin chains. The interaction between UBXN1 and autoubiquitinated BRCA1, leads to the inhibition the E3 ubiquitin-protein ligase activity of the BRCA1-BARD1 heterodimer. UBXN1 is also a component of a complex required to couple deglycosylation and proteasome-mediated degradation of misfolded proteins in the endoplasmic reticulum that are retrotranslocated in the cytosol.3 kDa protein, UBXD10, 2B28, and SAKS1.
UniGene ID
Hs.351296
UniProt ID (eCommerce)
Q04323

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.