human UBQLN1 shRNA silencing AAV

Name 
AAV-h-UBQLN1-shRNA
Cat No 
shAAV-227070
Availability
4-5 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human UBQLN1.

shAAV-227070
AAV-h-UBQLN1-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human UBQLN1 (ubiquilin 1). Available with optional GFP reporter or cell-specific promoter.

Request a Quote

Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
90
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
DA41; DSK2; hPLIC-1; PLIC-1; protein linking IAP with cytoskeleton 1; testicular tissue protein Li 219; ubiquilin-1; UBQN; XDRP1
Description (eCommerce)
UBQLN1 plays an important role in the regulation of protein degradation mechanisms and pathways including ubiquitin-proteasome system (UPS), autophagy and endoplasmic reticulum-associated protein degradation (ERAD) pathway. UBQLN1 also contributes to proteasomeal degradation, the ERAD pathway, the unfolded protein response, autophagy, and TLR signaling (Uniprot Q9UMX0).
Description (Vector)
UBQLN1 encodes an ubiquitin-like protein (ubiquilin) that shares a high degree of similarity with related products in yeast, rat and frog. Ubiquilins contain an N-terminal ubiquitin-like domain and a C-terminal ubiquitin-associated domain. They physically associate with both proteasomes and ubiquitin ligases, and thus are thought to functionally link the ubiquitination machinery to the proteasome to affect in vivo protein degradation. This ubiquilin has also been shown to modulate accumulation of presenilin proteins, and it is found in lesions associated with Alzheimer's and Parkinson's disease. Two transcript variants encoding different isoforms have been found for this gene.
Gene ID
29979
Gene Name (eCommerce)
ubiquilin 1
Gene Name (Vector)
ubiquilin 1
Gene Symbol
UBQLN1
HGNC ID
HGNC:12508
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1770
ORF Size (bp)
1770 bp
Protein Name (eCommerce)
Ubiquilin-1
RefSeq ID
NM_013438
RefSeq Synonyms
NM_053067, NM_013438, BC039294, BC010066,
Research Areas
Apoptosis,Complexome,Hypoxia,Neurobiology,Proteasome,Signal Transduction
Research Areas (Faceted)
cell_biology,neurobiology,signal_transduction
Species
human
Target Sentence
UBQLN1 plays an important role in the regulation of protein degradation mechanisms and pathways including ubiquitin-proteasome system (UPS), autophagy and endoplasmic reticulum-associated protein degradation (ERAD) pathway. UBQLN1 also contributes to proteasomeal degradation, the ERAD pathway, the unfolded protein response, autophagy, and TLR signaling (Uniprot Q9UMX0).
UniGene ID
Hs.9589
UniProt ID (eCommerce)
Q9UMX0

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.