human UBE2C shRNA silencing AAV

Name
AAV-h-UBE2C-shRNA

Cat No
shAAV-226991

Availability
4-5 weeks

This is an AAV expressing shRNA for silencing of Human UBE2C.

shAAV-226991

AAV-h-UBE2C-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human UBE2C (ubiquitin conjugating enzyme E2 C). Available with optional GFP reporter or cell-specific promoter.

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Vector Designer

Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

dJ447F3.2; UBCH10

Description (Vector)

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is required for the destruction of mitotic cyclins and for cell cycle progression. Multiple transcript variants encoding different isoforms have been found for this gene.

Gene ID

11065

Gene Name (Vector)

ubiquitin conjugating enzyme E2 C

Gene Symbol

UBE2C

HGNC ID

HGNC:15937

ORF Size (aa)

540

RefSeq ID

NM_007019

RefSeq Synonyms

NM_181803, NM_181802, NM_181801, NM_181800, NM_181799, NM_007019, NM_001281742, NM_001281741, BC050736, BC016292, BC007656,

Species

human

UniGene ID

Hs.93002

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.