human UBA3 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human UBA3.
shAAV-226962
AAV-h-UBA3-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human UBA3 (ubiquitin like modifier activating enzyme 3). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
hUBA3; NAE2; UBE1C
Description (Vector)
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E1 ubiquitin-activating enzyme family. The encoded enzyme associates with AppBp1, an amyloid beta precursor protein binding protein, to form a heterodimer, and then the enzyme complex activates NEDD8, a ubiquitin-like protein, which regulates cell division, signaling and embryogenesis. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
Gene ID
9039
Gene Name (Vector)
ubiquitin like modifier activating enzyme 3
Gene Symbol
UBA3
HGNC ID
HGNC:12470
ORF Size (aa)
1392
ORF Size (bp)
1392 bp
RefSeq ID
NM_003968
RefSeq Synonyms
NM_198195, NM_003968, BC022853,
Species
human
UniGene ID
Hs.154320
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.