human TYR shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human TYR.
shAAV-226938
AAV-h-TYR-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human TYR (tyrosinase). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
ATN; CMM8; OCA1; OCA1A; OCAIA; SHEP3
Description (Vector)
The enzyme encoded by this gene catalyzes the first 2 steps, and at least 1 subsequent step, in the conversion of tyrosine to melanin. The enzyme has both tyrosine hydroxylase and dopa oxidase catalytic activities, and requires copper for function. Mutations in this gene result in oculocutaneous albinism, and nonpathologic polymorphisms result in skin pigmentation variation. The human genome contains a pseudogene similar to the 3' half of this gene.
Gene ID
7299
Gene Name (Vector)
tyrosinase
Gene Symbol
TYR
HGNC ID
HGNC:12442
ORF Size (aa)
1134
RefSeq ID
NM_000372
RefSeq Synonyms
NM_000372, BC027179,
Species
human
UniGene ID
Hs.503555
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.