human TXNRD1 shRNA silencing AAV

Name 
AAV-h-TXNRD1-shRNA
Cat No 
shAAV-226929
Availability
4-5 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human TXNRD1.

shAAV-226929
AAV-h-TXNRD1-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human TXNRD1 (thioredoxin reductase 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
90
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
gene associated with retinoic and IFN-induced mortality 12 protein; gene associated with retinoic and interferon-induced mortality 12 protein; GRIM-12; KM-102-derived reductase-like factor; oxidoreductase; testis tissue sperm-binding protein Li 46a; thioredoxin reductase 1, cytoplasmic; thioredoxin reductase GRIM-12; thioredoxin reductase TR1; TR; TR1; TRXR1; TXNR
Description (eCommerce)
Thioredoxin Reductase 1 may possess glutaredoxin activity as well as thioredoxin reductase activity and induces actin and tubulin polymerization, leading to formation of cell membrane protrusions [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q16881].
Description (Vector)
TXNRD1 encodes a member of the family of pyridine nucleotide oxidoreductases. This protein reduces thioredoxins as well as other substrates, and plays a role in selenium metabolism and protection against oxidative stress. The functional enzyme is thought to be a homodimer which uses FAD as a cofactor. Each subunit contains a selenocysteine (Sec) residue which is required for catalytic activity. The selenocysteine is encoded by the UGA codon that normally signals translation termination. The 3' UTR of selenocysteine-containing genes have a common stem-loop structure, the sec insertion sequence (SECIS), that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Alternative splicing results in several transcript variants encoding the same or different isoforms.
Gene ID
7296
Gene Name (eCommerce)
thioredoxin reductase 1
Gene Name (Vector)
thioredoxin reductase 1
Gene Symbol
TXNRD1
HGNC ID
HGNC:12437
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1500
ORF Size (bp)
1500 bp
Protein Name (eCommerce)
Thioredoxin reductase 1, cytoplasmic
RefSeq ID
NM_182743
RefSeq Synonyms
NM_182743, NM_182742, NM_182729, NM_003330, NM_001261446, NM_001261445, NM_001093771, BC018122,
Research Areas
Immunology,Metabolism/Metabolic Process,Mitochondrion,Signal Transduction,T-cell Receptor Signaling
Research Areas (Faceted)
signal_transduction,immunology,metabolism,cell_biology,signal_transduction,immunology
Species
human
Target Sentence
Thioredoxin Reductase 1 may possess glutaredoxin activity as well as thioredoxin reductase activity and induces actin and tubulin polymerization, leading to formation of cell membrane protrusions [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q16881].
UniGene ID
Hs.708065
UniProt ID (eCommerce)
Q16881

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About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.