human TTC7A shRNA silencing AAV

Name
AAV-h-TTC7A-shRNA

Cat No
shAAV-226725

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Human TTC7A.

shAAV-226725

AAV-h-TTC7A-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human TTC7A (tetratricopeptide repeat domain 7A). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

GIDID; MINAT; tetratricopeptide repeat protein 7A; TPR repeat protein 7A; TTC7

Description (eCommerce)

Tetratricopeptide repeat protein 7A (TTC7A) is a protein containing tetratricopeptide repeats. Mutations in the TTC7A gene disrupt intestinal development and can cause early onset inflammatory bowel disease and intestinal atresia [taken from NCBI Entrez Gene (Gene ID: 57217)].

Description (Vector)

The tetratricopeptide repeat (TPR) domain is defined by a degenerate consensus sequence of 34 amino acids. TPR domain-containing proteins, such as TTC7A, have diverse functions in cell cycle control, protein transport, phosphate turnover, and protein trafficking or secretion, and they can act as chaperones or scaffolding proteins (White et al., 2005 (PubMed 15718100)).(supplied by OMIM, Mar 2008)

Gene ID

57217

Gene Name (eCommerce)

tetratricopeptide repeat domain 7A

Gene Name (Vector)

tetratricopeptide repeat domain 7A

Gene Symbol

TTC7A

HGNC ID

HGNC:19750

NCBI Taxonomy ID (eCommerce)

9606.0

ORF Size (aa)

1515

ORF Size (bp)

1515 bp

Protein Name (eCommerce)

Tetratricopeptide repeat protein 7A

RefSeq ID

NM_020458

RefSeq Synonyms

NM_020458, NM_001288955, NM_001288953, NM_001288951, BC114365, BC111487,

Research Areas

Cell Biology,Translational Control

Research Areas (Faceted)

cell_biology,transcription_translation

Species

human

Target Sentence

Tetratricopeptide repeat protein 7A (TTC7A) is a protein containing tetratricopeptide repeats. Mutations in the TTC7A gene disrupt intestinal development and can cause early onset inflammatory bowel disease and intestinal atresia [taken from NCBI Entrez Gene (Gene ID: 57217)].

UniGene ID

Hs.370603

UniProt ID (eCommerce)

Q9ULT0

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.