human TRPC4 shRNA silencing AAV

Name
AAV-h-TRPC4-shRNA

Cat No
shAAV-226540

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Human TRPC4.

shAAV-226540

AAV-h-TRPC4-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human TRPC4 (transient receptor potential cation channel subfamily C member 4). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

HTRP-4; HTRP4; TRP4

Description (Vector)

TRPC4 encodes a member of the canonical subfamily of transient receptor potential cation channels. The encoded protein forms a non-selective calcium-permeable cation channel that is activated by Gq-coupled receptors and tyrosine kinases, and plays a role in multiple processes including endothelial permeability, vasodilation, neurotransmitter release and cell proliferation. Single nucleotide polymorphisms in this gene may be associated with generalized epilepsy with photosensitivity. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

Gene ID

7223

Gene Name (Vector)

transient receptor potential cation channel subfamily C member 4

Gene Symbol

TRPC4

HGNC ID

HGNC:12336

ORF Size (aa)

2934

ORF Size (bp)

2934 bp

RefSeq ID

NM_016179

RefSeq Synonyms

NM_016179, NM_003306, NM_001135958, NM_001135957, NM_001135956, NM_001135955, BC105917, BC105641, BC104725,

Species

human

UniGene ID

Hs.262960

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.