Promotional banner reading 'FALL SAVINGS' with expiry date August 31 on an orange background; features a group of people with orange stacked blocks on the right and discounts for services and catalog products.

human TRIP6 shRNA silencing AAV

Name 
AAV-h-TRIP6-shRNA
Cat No 
shAAV-226506
Availability
4-5 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human TRIP6.

shAAV-226506
AAV-h-TRIP6-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human TRIP6 (thyroid hormone receptor interactor 6). Available with optional GFP reporter or cell-specific promoter.

Request a Quote

Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
90
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
OIP1; OIP-1; OPA-interacting protein 1; thyroid hormone receptor interacting protein 6; thyroid receptor-interacting protein 6; TR-interacting protein 6; TRIP-6; TRIP6i2; ZRP-1; zyxin related protein 1; Zyxin-related protein 1
Description (eCommerce)
Thyroid receptor interacting protein 6 (TRIP6) was identified as a protein that interacts with the thyroid receptor. TRIP6 is a LIM domain-containing protein and is in the same family as the adhesion plaque protein, zyxin and lipoma preferred partner (LPP). TRIP6 has been shown to localize to focal adhesion plaques as well as to the nucleus where it can act as a co-activator of transcription. Thus, it has been implicated as playing a role in cytoskeletal organization and the relay of cell signals from focal adhesion plaques to the nucleus. Alternative names for TRIP6 include OPA-interacting protein 1, OIP1, Zyxin-related protein 1 ZRP-1, MGC3837, MGC4423, MGC10556, MGC10558, and MGC29959.
Description (Vector)
TRIP6 is a member of the zyxin family and encodes a protein with three LIM zinc-binding domains. This protein localizes to focal adhesion sites and along actin stress fibers. Recruitment of this protein to the plasma membrane occurs in a lysophosphatidic acid (LPA)-dependent manner and it regulates LPA-induced cell migration. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized.
Gene ID
7205
Gene Name (eCommerce)
thyroid hormone receptor interactor 6
Gene Name (Vector)
thyroid hormone receptor interactor 6
Gene Symbol
TRIP6
HGNC ID
HGNC:12311
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1425
ORF Size (bp)
1425 bp
Protein Name (eCommerce)
Thyroid receptor-interacting protein 6
RefSeq ID
NM_003302
RefSeq Synonyms
NM_003302, BC028985, BC021540, BC004999, BC004249, BC002680,
Research Areas
Cytoskeleton,EGFR Signaling,Interleukin Signaling,Nuclear Receptor Coactivators,Signal Transduction,Transcription Factor/Regulator
Research Areas (Faceted)
cell_biology,immunology,signal_transduction,transcription_translation
Species
human
Target Sentence
Thyroid receptor interacting protein 6 (TRIP6) was identified as a protein that interacts with the thyroid receptor. TRIP6 is a LIM domain-containing protein and is in the same family as the adhesion plaque protein, zyxin and lipoma preferred partner (LPP). TRIP6 has been shown to localize to focal adhesion plaques as well as to the nucleus where it can act as a co-activator of transcription. Thus, it has been implicated as playing a role in cytoskeletal organization and the relay of cell signals from focal adhesion plaques to the nucleus. Alternative names for TRIP6 include OPA-interacting protein 1, OIP1, Zyxin-related protein 1 ZRP-1, MGC3837, MGC4423, MGC10556, MGC10558, and MGC29959.
UniGene ID
Hs.534360
UniProt ID (eCommerce)
Q15654

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.