human TRIM16 shRNA silencing AAV

Name 
AAV-h-TRIM16-shRNA
Cat No 
shAAV-226402
Availability
6-8 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human TRIM16.

shAAV-226402
AAV-h-TRIM16-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human TRIM16 (tripartite motif containing 16). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
EBBP; estrogen-responsive B box protein; tripartite motif-containing protein 16
Description (eCommerce)
TRIM16/EBBP is a member of the tripartite motif RBCC/Trim domain family that contains a RING-finger domain, B-boxes, and an alpha-helical coiled-coil region. TRIM16/EBBP has been identified as an estrogen and anti-estrogen regulated gene in keratinocytes and may be important for keratinocyte differentiation. Studies show that TRIM16/EBBP also plays a role in interleukin-1beta cytokine secretion and transactivation of the retinoic acid response element beta (betaRARE).
Description (Vector)
TRIM16 was identified as an estrogen and anti-estrogen regulated gene in epithelial cells stably expressing estrogen receptor. The protein encoded by this gene contains two B box domains and a coiled-coiled region that are characteristic of the B box zinc finger protein family. The proteins of this family have been reported to be involved in a variety of biological processes including cell growth, differentiation and pathogenesis. Expression of this gene was detected in most tissues. Its function, however, has not yet been determined.
Gene ID
10626
Gene Name (eCommerce)
tripartite motif containing 16
Gene Name (Vector)
tripartite motif containing 16
Gene Symbol
TRIM16
HGNC ID
HGNC:17241
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1695
ORF Size (bp)
1695 bp
Protein Name (eCommerce)
Tripartite motif-containing protein 16
RefSeq ID
NM_006470
RefSeq Synonyms
NM_006470, BC067096, BC053514,
Research Areas
Histone Modification,Interleukin Signaling,Signal Transduction,Transcription Factor/Regulator,Zinc-finger
Research Areas (Faceted)
cell_biology,immunology,signal_transduction,transcription_translation
Species
human
Target Sentence
TRIM16/EBBP is a member of the tripartite motif RBCC/Trim domain family that contains a RING-finger domain, B-boxes, and an alpha-helical coiled-coil region. TRIM16/EBBP has been identified as an estrogen and anti-estrogen regulated gene in keratinocytes and may be important for keratinocyte differentiation. Studies show that TRIM16/EBBP also plays a role in interleukin-1beta cytokine secretion and transactivation of the retinoic acid response element beta (betaRARE).
UniGene ID
Hs.123534
UniProt ID (eCommerce)
O95361

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.