human TRAFD1 shRNA silencing AAV

Name 
AAV-h-TRAFD1-shRNA
Cat No 
shAAV-226335
Availability
4-5 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human TRAFD1.

shAAV-226335
AAV-h-TRAFD1-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human TRAFD1 (TRAF-type zinc finger domain containing 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
80
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
FLN29; FLN29 gene product; Protein FLN29; TRAF-type zinc finger domain-containing protein 1
Description (eCommerce)
FLN29 is a negative feedback regulator that controls excessive innate immune responses. It regulates both Toll-like receptor 4 (TLR4) and DDX58/RIG1-like helicases (RLH) pathways. FLN29 may inhibit the LTR pathway by direct interaction with TRAF6 and attenuation of NF-kappa-B activation It may negatively regulate the RLH pathway downstream from MAVS and upstream of NF-kappa-B and IRF3 (By similarity) [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/O14545].
Description (Vector)
The innate immune system confers host defense against viral and microbial infection, and TRAFD1 is a negative feedback regulator that controls excessive immune responses (Sanada et al., 2008 (PubMed 18849341)).(supplied by OMIM, Dec 2009)
Gene ID
10906
Gene Name (eCommerce)
TRAF-type zinc finger domain containing 1
Gene Name (Vector)
TRAF-type zinc finger domain containing 1
Gene Symbol
TRAFD1
HGNC ID
HGNC:24808
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1749
ORF Size (bp)
1749 bp
Protein Name (eCommerce)
TRAF-type zinc finger domain-containing protein 1
RefSeq ID
NM_006700
RefSeq Synonyms
NM_006700, NM_001143906, BC003553,
Research Areas
Immunology,Signal Transduction,Toll-like Receptor Signaling,Zinc-finger
Research Areas (Faceted)
signal_transduction,immunology,cell_biology
Species
human
Target Sentence
FLN29 is a negative feedback regulator that controls excessive innate immune responses. It regulates both Toll-like receptor 4 (TLR4) and DDX58/RIG1-like helicases (RLH) pathways. FLN29 may inhibit the LTR pathway by direct interaction with TRAF6 and attenuation of NF-kappa-B activation It may negatively regulate the RLH pathway downstream from MAVS and upstream of NF-kappa-B and IRF3 (By similarity) [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/O14545].
UniGene ID
Hs.5148
UniProt ID (eCommerce)
O14545

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.