human TRAF2 shRNA silencing AAV

E3 ubiquitin-protein ligase TRAF2; MGC:45012; RING-type E3 ubiquitin transferase TRAF2; RNF117; TNF receptor-associated factor 2; TRAP; TRAP3; tumor necrosis factor type 2 receptor associated protein 3; Tumor necrosis factor type 2 receptor-associated protein 3

TNF receptor-associated factor 2 (TRAF2) regulates activation of NF-kappa-B and JNK and plays a central role in the regulation of cell survival and apoptosis. TRAF2 is required for normal antibody isotype switching from IgM to IgG. TRAF2 has E3 ubiquitin-protein ligase activity and promotes 'Lys-63'-linked ubiquitination of target proteins, such as BIRC3, RIPK1 and TICAM1. TRAF2 is an essential constituent of several E3 ubiquitin-protein ligase complexes, where it promotes the ubiquitination of target proteins by bringing them into contact with other E3 ubiquitin ligases [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/ Q12933].

TRAF2 is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins associate with, and mediate the signal transduction from members of the TNF receptor superfamily. This protein directly interacts with TNF receptors, and forms a heterodimeric complex with TRAF1. This protein is required for TNF-alpha-mediated activation of MAPK8/JNK and NF-kappaB. The protein complex formed by this protein and TRAF1 interacts with the inhibitor-of-apoptosis proteins (IAPs), and functions as a mediator of the anti-apoptotic signals from TNF receptors. The interaction of this protein with TRADD, a TNF receptor associated apoptotic signal transducer, ensures the recruitment of IAPs for the direct inhibition of caspase activation. BIRC2/c-IAP1, an apoptosis inhibitor possessing ubiquitin ligase activity, can unbiquitinate and induce the degradation of this protein, and thus potentiate TNF-induced apoptosis. Multiple alternatively spliced transcript variants have been found for this gene, but the biological validity of only one transcript has been determined.

7186

TNF receptor associated factor 2

TNF receptor associated factor 2

TRAF2

HGNC:12032

9606.0

1506

1506 bp

TNF receptor-associated factor 2

NM_021138

NM_021138, BC064662, BC043492, BC033810, BC032410,

Apoptosis,Cancer,CD40 Signaling,Host-Virus Interactions,IFN Signaling,Immunology,Innate Immunity,JNK Signaling,Lung Cancer,MAPK Signaling,Neurobiology,Neurodevelopment,NF-kB Signaling,RANKL-RANK Signaling,Signal Transduction,TNF Signaling,TRAIL Signaling,TWEAK Signaling,Ubiquitination,Viral Carcinogenesis,Zinc-finger

cancer,cell_biology,developmental_biology,immunology,infectious_disease,neurobiology,signal_transduction

human

TNF receptor-associated factor 2 (TRAF2) regulates activation of NF-kappa-B and JNK and plays a central role in the regulation of cell survival and apoptosis. TRAF2 is required for normal antibody isotype switching from IgM to IgG. TRAF2 has E3 ubiquitin-protein ligase activity and promotes 'Lys-63'-linked ubiquitination of target proteins, such as BIRC3, RIPK1 and TICAM1. TRAF2 is an essential constituent of several E3 ubiquitin-protein ligase complexes, where it promotes the ubiquitination of target proteins by bringing them into contact with other E3 ubiquitin ligases [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/ Q12933].

Hs.522506

Q12933