human TRADD shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human TRADD.
shAAV-226319
AAV-h-TRADD-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human TRADD (TNFRSF1A associated via death domain). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
Hs.89862
Description (Vector)
TRADD is a death domain containing adaptor molecule that interacts with TNFRSF1A/TNFR1 and mediates programmed cell death signaling and NF-kappaB activation. This protein binds adaptor protein TRAF2, reduces the recruitment of inhibitor-of-apoptosis proteins (IAPs) by TRAF2, and thus suppresses TRAF2 mediated apoptosis. This protein can also interact with receptor TNFRSF6/FAS and adaptor protein FADD/MORT1, and is involved in the Fas-induced cell death pathway.
Gene ID
8717
Gene Name (Vector)
TNFRSF1A associated via death domain
Gene Symbol
TRADD
HGNC ID
HGNC:12030
ORF Size (aa)
939
RefSeq ID
NM_003789
RefSeq Synonyms
NM_003789, NM_001323552, BC004491,
Species
human
UniGene ID
Hs.460996
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.