human TPSG1 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human TPSG1.
shAAV-226303
AAV-h-TPSG1-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human TPSG1 (tryptase gamma 1). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
PRSS31; TMT; trpA
Description (Vector)
Tryptases comprise a family of trypsin-like serine proteases, the peptidase family S1. Tryptases are enzymatically active only as heparin-stabilized tetramers, and they are resistant to all known endogenous proteinase inhibitors. Several tryptase genes are clustered on chromosome 16p13.3. There is uncertainty regarding the number of genes in this cluster. Currently four functional genes - alpha I, beta I, beta II and gamma I - have been identified. And beta I has an allelic variant named alpha II, beta II has an allelic variant beta III, also gamma I has an allelic variant gamma II. Beta tryptases appear to be the main isoenzymes expressed in mast cells; whereas in basophils, alpha-tryptases predominant. This gene differs from other members of the tryptase gene family in that it has C-terminal hydrophobic domain, which may serve as a membrane anchor. Tryptases have been implicated as mediators in the pathogenesis of asthma and other allergic and inflammatory disorders.
Gene ID
25823
Gene Name (Vector)
tryptase gamma 1
Gene Symbol
TPSG1
HGNC ID
HGNC:14134
ORF Size (aa)
966
RefSeq ID
NM_012467
RefSeq Synonyms
NM_012467, BC172313,
Species
human
UniGene ID
Hs.592076
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.