human TPCN2 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human TPCN2.
shAAV-226249
AAV-h-TPCN2-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human TPCN2 (two pore segment channel 2). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
SHEP10; TPC2
Description (Vector)
TPCN2 encodes a putative cation-selective ion channel with two repeats of a six-transmembrane-domain. The protein localizes to lysosomal membranes and enables nicotinic acid adenine dinucleotide phosphate (NAADP) -induced calcium ion release from lysosome-related stores. This ubiquitously expressed gene has elevated expression in liver and kidney. Two common nonsynonymous SNPs in this gene strongly associate with blond versus brown hair pigmentation.
Gene ID
219931
Gene Name (Vector)
two pore segment channel 2
Gene Symbol
TPCN2
HGNC ID
HGNC:20820
ORF Size (aa)
2259
ORF Size (bp)
2259 bp
RefSeq ID
NM_139075
RefSeq Synonyms
NM_139075, BC063008,
Species
human
UniGene ID
Hs.131851
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.