human TP53BP1 shRNA silencing AAV

Name 
AAV-h-TP53BP1-shRNA
Cat No 
shAAV-226230
Availability
4-5 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human TP53BP1.

shAAV-226230
AAV-h-TP53BP1-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human TP53BP1 (tumor protein p53 binding protein 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
80
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
53BP1; p202; p53-binding protein 1; p53BP1; TDRD30; TP53-binding protein 1; tumor protein 53-binding protein, 1; tumor suppressor p53-binding protein 1
Description (eCommerce)
53BP1 (p53 Binding Protein 1) is an early participant in the cellular response to DNA double-strand breaks. 53BP1 functions in a redundant role in phosphorylation of the downstream checkpoint effector proteins Brca1 and Chk2 but was required for the formation of Brca1 foci in a hierarchical branched pathway for the recruitment of repair and signaling proteins to sites of DNA damage.
Gene ID
7158
Gene Name (eCommerce)
tumor protein p53 binding protein 1
Gene Name (Vector)
tumor protein p53 binding protein 1
Gene Symbol
TP53BP1
HGNC ID
HGNC:11999
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
5919
ORF Size (bp)
5919 bp
Protein Name (eCommerce)
Tumor suppressor p53-binding protein 1
RefSeq ID
NM_005657
RefSeq Synonyms
NM_005657, NM_001141980, NM_001141979, BC112161,
Research Areas
Cell Cycle,DNA Damage/Repair,Homologous Recombination,Phospho-specific,Replication,Transcription Factor/Regulator
Research Areas (Faceted)
cell_biology,cell_cycle,genetics,transcription_translation
Species
human
Target Sentence
53BP1 (p53 Binding Protein 1) is an early participant in the cellular response to DNA double-strand breaks. 53BP1 functions in a redundant role in phosphorylation of the downstream checkpoint effector proteins Brca1 and Chk2 but was required for the formation of Brca1 foci in a hierarchical branched pathway for the recruitment of repair and signaling proteins to sites of DNA damage.
UniGene ID
Hs.440968
UniProt ID (eCommerce)
Q12888

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About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.