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human TNKS1BP1 shRNA silencing AAV

Name 
AAV-h-TNKS1BP1-shRNA
Cat No 
shAAV-226123
Availability
4-5 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human TNKS1BP1.

shAAV-226123
AAV-h-TNKS1BP1-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human TNKS1BP1 (tankyrase 1 binding protein 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
80
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
182 kDa tankyrase-1-binding protein; TAB182; tankyrase 1 binding protein 1, 182kDa; tankyrase 1-binding protein of 182 kDa; testis secretory sperm-binding protein Li 206a
Description (eCommerce)
TAB182 (tankyrase 1-binding protein of 182 kDa) was identified in a two-hybrid screen in search of tankyrase 1-interacting proteins. Tankyrase 1 is a poly (ADP-ribose) polymerase (PARP) that ribosylates the negative regulator of telomere length, TRF1 (telomere-repeat binding factor). Ribosylation of TRF1 has been shown to result in the inhibition of TRF1 binding and an induction of telomere elongation. TAB182 and TRF1 bind multiple discrete and overlapping sites of the tankyrase 1 ankyrin domain. This finding suggests that TAB182 may act as a scaffold to mediate higher order protein complex formation at telomeres. TAB182 has also been suggested to serve a role in the cytoplasm as it has been found to localize to the cytoplasmic cortical actin network.
Gene ID
85456
Gene Name (eCommerce)
tankyrase 1 binding protein 1
Gene Name (Vector)
tankyrase 1 binding protein 1
Gene Symbol
TNKS1BP1
HGNC ID
HGNC:19081
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
5190
ORF Size (bp)
5190 bp
Protein Name (eCommerce)
182 kDa tankyrase-1-binding protein
RefSeq ID
NM_033396
RefSeq Synonyms
NM_033396, BC150333,
Research Areas
Cytoskeleton,Gene Expression,RNA Processing,Telomeric Maintenance
Research Areas (Faceted)
cell_biology,genetics,transcription_translation
Species
human
Target Sentence
TAB182 (tankyrase 1-binding protein of 182 kDa) was identified in a two-hybrid screen in search of tankyrase 1-interacting proteins. Tankyrase 1 is a poly (ADP-ribose) polymerase (PARP) that ribosylates the negative regulator of telomere length, TRF1 (telomere-repeat binding factor). Ribosylation of TRF1 has been shown to result in the inhibition of TRF1 binding and an induction of telomere elongation. TAB182 and TRF1 bind multiple discrete and overlapping sites of the tankyrase 1 ankyrin domain. This finding suggests that TAB182 may act as a scaffold to mediate higher order protein complex formation at telomeres. TAB182 has also been suggested to serve a role in the cytoplasm as it has been found to localize to the cytoplasmic cortical actin network.
UniGene ID
Hs.530730
UniProt ID (eCommerce)
Q9C0C2

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.