human TNFRSF14 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human TNFRSF14.
shAAV-226079
AAV-h-TNFRSF14-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human TNFRSF14 (TNF receptor superfamily member 14). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
ATAR; CD antigen CD270; CD270; CD40-like protein; herpes virus entry mediator A; Herpesvirus entry mediator A; HVEA; HVEM; LIGHTR; TR2; tumor necrosis factor receptor superfamily member 14; tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator); Tumor necrosis factor receptor-like 2; tumor necrosis factor receptor-like gene2
Description (eCommerce)
HVEM/TNFRSF14 is a member of the tumor necrosis factor receptor superfamily. It functions in signal transduction pathways that activate inflammatory and inhibitory T-cell immune response. HVEM/ TNFRSF14 also binds herpes simplex virus (HSV) viral envelope glycoprotein D (gD), mediating its entry into cells. [taken from NCBI Entrez Gene (Gene ID: 8764)].
Description (Vector)
TNFRSF14 is a member of the TNF-receptor superfamily. This receptor was identified as a cellular mediator of herpes simplex virus (HSV) entry. Binding of HSV viral envelope glycoprotein D (gD) to this receptor protein has been shown to be part of the viral entry mechanism. The cytoplasmic region of this receptor was found to bind to several TRAF family members, which may mediate the signal transduction pathways that activate the immune response.
Gene ID
8764
Gene Name (eCommerce)
TNF receptor superfamily member 14
Gene Name (Vector)
TNF receptor superfamily member 14
Gene Symbol
TNFRSF14
HGNC ID
HGNC:11912
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
600
Protein Name (eCommerce)
Tumor necrosis factor receptor superfamily member 14
RefSeq ID
NM_003820
RefSeq Synonyms
NM_003820, NM_001297605, BC029848, BC002794,
Research Areas
Cancer,Host-Virus Interactions,Immunology,Signal Transduction
Research Areas (Faceted)
cancer,signal_transduction,infectious_disease,immunology
Species
human
Target Sentence
HVEM/TNFRSF14 is a member of the tumor necrosis factor receptor superfamily. It functions in signal transduction pathways that activate inflammatory and inhibitory T-cell immune response. HVEM/ TNFRSF14 also binds herpes simplex virus (HSV) viral envelope glycoprotein D (gD), mediating its entry into cells. [taken from NCBI Entrez Gene (Gene ID: 8764)].
UniGene ID
Hs.512898
UniProt ID (eCommerce)
Q92956
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.