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human TMPRSS3 shRNA silencing AAV

Name 
AAV-h-TMPRSS3-shRNA
Cat No 
shAAV-226014
Availability
6-8 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human TMPRSS3.

shAAV-226014
AAV-h-TMPRSS3-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human TMPRSS3 (transmembrane protease, serine 3). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
DFNB10; DFNB8; ECHOS1; TADG12
Description (Vector)
TMPRSS3 encodes a protein that belongs to the serine protease family. The encoded protein contains a serine protease domain, a transmembrane domain, an LDL receptor-like domain, and a scavenger receptor cysteine-rich domain. Serine proteases are known to be involved in a variety of biological processes, whose malfunction often leads to human diseases and disorders. TMPRSS3 was identified by its association with both congenital and childhood onset autosomal recessive deafness. TMPRSS3 is expressed in fetal cochlea and many other tissues, and is thought to be involved in the development and maintenance of the inner ear or the contents of the perilymph and endolymph. TMPRSS3 was also identified as a tumor-associated gene that is overexpressed in ovarian tumors. Alternatively spliced transcript variants have been described.
Gene ID
64699
Gene Name (Vector)
transmembrane protease, serine 3
Gene Symbol
TMPRSS3
HGNC ID
HGNC:11877
ORF Size (aa)
1362
ORF Size (bp)
1362 bp
RefSeq ID
NM_024022
RefSeq Synonyms
NM_032405, NM_032404, NM_024022, NM_001256317, BC074847, BC074846,
Species
human
UniGene ID
Hs.208600

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.