human TMEM43 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human TMEM43.
shAAV-225899
AAV-h-TMEM43-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human TMEM43 (transmembrane protein 43). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
ARVC5; ARVD5; EDMD7; LUMA
Description (Vector)
TMEM43 belongs to the TMEM43 family. Defects in this gene are the cause of familial arrhythmogenic right ventricular dysplasia type 5 (ARVD5), also known as arrhythmogenic right ventricular cardiomyopathy type 5 (ARVC5). Arrhythmogenic right ventricular dysplasia is an inherited disorder, often involving both ventricles, and is characterized by ventricular tachycardia, heart failure, sudden cardiac death, and fibrofatty replacement of cardiomyocytes. TMEM43 contains a response element for PPAR gamma (an adipogenic transcription factor), which may explain the fibrofatty replacement of the myocardium, a characteristic pathological finding in ARVC.
Gene ID
79188
Gene Name (Vector)
transmembrane protein 43
Gene Symbol
TMEM43
HGNC ID
HGNC:28472
ORF Size (aa)
1203
RefSeq ID
NM_024334
RefSeq Synonyms
NM_024334, BC011719, BC008054, BC003125,
Species
human
UniGene ID
Hs.517817
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.