human TMEM33 shRNA silencing AAV

Name 
AAV-h-TMEM33-shRNA
Cat No 
shAAV-225886
Availability
4-5 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human TMEM33.

shAAV-225886
AAV-h-TMEM33-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human TMEM33 (transmembrane protein 33). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
90
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
1600019D15Rik; Protein DB83; SHINC3; SHINC-3; transmembrane protein 33
Description (eCommerce)
Transmembrane protein 33 (TMEM33) acts as a regulator of the tubular endoplasmic reticulum (ER) network. It suppresses the RTN3/4-induced formation of the ER tubules (PubMed:25612671). TMEM33 positively regulates PERK-mediated and IRE1-mediated unfolded protein response signaling (PubMed:26268696) [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/P57088].
Gene ID
55161
Gene Name (eCommerce)
transmembrane protein 33
Gene Name (Vector)
transmembrane protein 33
Gene Symbol
TMEM33
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
744
ORF Size (bp)
744 bp
Protein Name (eCommerce)
Transmembrane protein 33
RefSeq ID
NM_018126
RefSeq Synonyms
NM_018126, BC000948,
Research Areas
Cell Biology,Transport
Research Areas (Faceted)
cell_biology
Species
human
Target Sentence
Transmembrane protein 33 (TMEM33) acts as a regulator of the tubular endoplasmic reticulum (ER) network. It suppresses the RTN3/4-induced formation of the ER tubules (PubMed:25612671). TMEM33 positively regulates PERK-mediated and IRE1-mediated unfolded protein response signaling (PubMed:26268696) [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/P57088].
UniGene ID
Hs.31082
UniProt ID (eCommerce)
P57088

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.