human TIAM1 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human TIAM1.
shAAV-225488
AAV-h-TIAM1-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human TIAM1 (T-cell lymphoma invasion and metastasis 1). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
human T-lymphoma invasion and metastasis inducing TIAM1 protein; TIAM-1; T-lymphoma invasion and metastasis-inducing protein 1
Description (eCommerce)
T lymphoma invasion and metastasis-inducing protein 1 (TIAM1) is a guanine-nucleotide exchange factor (GEF) that positively regulates the Rac1-GTPase. Through Rac1, TIAM1 promotes cell migration and adhesion by modulating the actin cytoskeleton. TIAM1 was originally identified as a gene that induced invasion of lymphocytes.
Gene ID
7074
Gene Name (eCommerce)
T cell lymphoma invasion and metastasis 1
Gene Name (Vector)
T-cell lymphoma invasion and metastasis 1
Gene Symbol
TIAM1
HGNC ID
HGNC:11805
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
4596
ORF Size (bp)
4596 bp
Protein Name (eCommerce)
T-lymphoma invasion and metastasis-inducing protein 1
RefSeq ID
NM_003253
RefSeq Synonyms
NM_003253, BC143980, BC117196, BC117192,
Research Areas
Apoptosis,Axonogenesis,BDNF Signaling,Cancer,Cytoskeleton,GPCR Signaling,Neurobiology,NGF Signaling,PDGF Signaling,Rho Signaling,Signal Transduction,Translational Control
Research Areas (Faceted)
cancer,cell_biology,developmental_biology,neurobiology,signal_transduction,transcription_translation
Species
human
Target Sentence
T lymphoma invasion and metastasis-inducing protein 1 (TIAM1) is a guanine-nucleotide exchange factor (GEF) that positively regulates the Rac1-GTPase. Through Rac1, TIAM1 promotes cell migration and adhesion by modulating the actin cytoskeleton. TIAM1 was originally identified as a gene that induced invasion of lymphocytes.
UniGene ID
Hs.517228
UniProt ID (eCommerce)
Q13009
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.