human TGFB2 shRNA silencing AAV

Name
AAV-h-TGFB2-shRNA

Cat No
shAAV-225385

Availability
4-5 weeks

This is an AAV expressing shRNA for silencing of Human TGFB2.

shAAV-225385

AAV-h-TGFB2-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human TGFB2 (transforming growth factor beta 2). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

G-TSF; LDS4; TGF-beta2

Description (Vector)

TGFB2 encodes a member of the transforming growth factor beta (TGFB) family of cytokines, which are multifunctional peptides that regulate proliferation, differentiation, adhesion, migration, and other functions in many cell types by transducing their signal through combinations of transmembrane type I and type II receptors (TGFBR1 and TGFBR2) and their downstream effectors, the SMAD proteins. Disruption of the TGFB/SMAD pathway has been implicated in a variety of human cancers. The encoded protein is secreted and has suppressive effects of interleukin-2 dependent T-cell growth. Translocation t(1;7)(q41;p21) between this gene and HDAC9 is associated with Peters' anomaly, a congenital defect of the anterior chamber of the eye. The knockout mice lacking this gene show perinatal mortality and a wide range of developmental, including cardiac, defects. Alternatively spliced transcript variants encoding different isoforms have been identified.

Gene ID

7042

Gene Name (Vector)

transforming growth factor beta 2

Gene Symbol

TGFB2

HGNC ID

HGNC:11768

ORF Size (aa)

1245

ORF Size (bp)

1245 bp

RefSeq ID

NM_003238

RefSeq Synonyms

NM_003238, NM_001135599, BC099635, BC096235,

Species

human

UniGene ID

Hs.133379

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.