human TEK shRNA silencing AAV

Name
AAV-h-TEK-shRNA

Cat No
shAAV-225295

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Human TEK.

shAAV-225295

AAV-h-TEK-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human TEK (TEK receptor tyrosine kinase). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

CD202B; TIE-2; TIE2; VMCM; VMCM1

Description (Vector)

The TEK receptor tyrosine kinase is expressed almost exclusively in endothelial cells in mice, rats, and humans. This receptor possesses a unique extracellular domain containing 2 immunoglobulin-like loops separated by 3 epidermal growth factor-like repeats that are connected to 3 fibronectin type III-like repeats. The ligand for the receptor is angiopoietin-1. Defects in TEK are associated with inherited venous malformations; the TEK signaling pathway appears to be critical for endothelial cell-smooth muscle cell communication in venous morphogenesis. TEK is closely related to the TIE receptor tyrosine kinase.

Gene ID

7010

Gene Name (Vector)

TEK receptor tyrosine kinase

Gene Symbol

TEK

HGNC ID

HGNC:11724

ORF Size (aa)

3375

ORF Size (bp)

3375 bp

RefSeq ID

NM_000459

RefSeq Synonyms

NM_001290078, NM_001290077, NM_000459, BC035514,

Species

human

UniGene ID

Hs.89640

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.