human TDO2 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human TDO2.
shAAV-225263
AAV-h-TDO2-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human TDO2 (tryptophan 2,3-dioxygenase). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
TDO; TO; TPH2; TRPO
Description (Vector)
TDO2 encodes a heme enzyme that plays a critical role in tryptophan metabolism by catalyzing the first and rate-limiting step of the kynurenine pathway. Increased activity of the encoded protein and subsequent kynurenine production may also play a role in cancer through the suppression of antitumor immune responses, and single nucleotide polymorphisms in this gene may be associated with autism.
Gene ID
6999
Gene Name (Vector)
tryptophan 2,3-dioxygenase
Gene Symbol
TDO2
HGNC ID
HGNC:11708
ORF Size (aa)
1221
ORF Size (bp)
1221 bp
RefSeq ID
NM_005651
RefSeq Synonyms
NM_005651, BC005355,
Species
human
UniGene ID
Hs.183671
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.