human TCEA1 shRNA silencing AAV

Name
AAV-h-TCEA1-shRNA

Cat No
shAAV-225175

Availability
4-5 weeks

This is an AAV expressing shRNA for silencing of Human TCEA1.

shAAV-225175

AAV-h-TCEA1-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human TCEA1 (transcription elongation factor A1). Available with optional GFP reporter or cell-specific promoter.

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Vector Designer

Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

90

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

epididymis secretory sperm binding protein; GTF2S; SII; TCEA; TF2S; TFIIS; transcription elongation factor A (SII), 1; transcription elongation factor A protein 1; transcription elongation factor S-II protein 1; transcription elongation factor TFIIS.o; transcription factor IIS

Description (eCommerce)

Transcription elongation factor S-II protein 2 (TFIIS) is necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by S-II allows the resumption of elongation from the new 3'-terminus [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q15560].

Gene ID

6917

Gene Name (eCommerce)

transcription elongation factor A1

Gene Name (Vector)

transcription elongation factor A1

Gene Symbol

TCEA1

HGNC ID

HGNC:11612

NCBI Taxonomy ID (eCommerce)

9606.0

ORF Size (aa)

906

ORF Size (bp)

906 bp

Protein Name (eCommerce)

Transcription elongation factor A protein 1

RefSeq ID

NM_006756

RefSeq Synonyms

NM_201437, NM_006756, BC072460,

Research Areas

DNA Damage/Repair,Gene Expression,Host-Virus Interactions,Transcription Factor/Regulator,Zinc-finger

Research Areas (Faceted)

genetics,transcription_translation,infectious_disease,cell_biology

Species

human

Target Sentence

Transcription elongation factor S-II protein 2 (TFIIS) is necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by S-II allows the resumption of elongation from the new 3'-terminus [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q15560].

UniGene ID

Hs.491745

UniProt ID (eCommerce)

P23193

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.