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human TBCE shRNA silencing AAV

Name 
AAV-h-TBCE-shRNA
Cat No 
shAAV-225122
Availability
4-5 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human TBCE.

shAAV-225122
AAV-h-TBCE-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human TBCE (tubulin folding cofactor E). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
90
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
HRD; hypoparathyroidism, growth and mental retardation, and dysmorphism; KCS; KCS1; pac2; PEAMO; Tubulin-folding cofactor E; tubulin-specific chaperone E
Description (eCommerce)
Tubulin folding Cofactor E (TBCE) is one of four proteins (cofactors A, D, E, and C) involved in the pathway leading to correctly folded beta-tubulin from folding intermediates. Cofactors A and D are believed to play a role in capturing and stabilizing beta-tubulin intermediates in a quasi-native confirmation. Cofactor E binds to the cofactor D/beta-tubulin complex; interaction with cofactor C then causes the release of beta-tubulin polypeptides that are committed to the native stat.[taken from NCBI Entrez Gene (Gene ID: 6905)].
Description (Vector)
Cofactor E is one of four proteins (cofactors A, D, E, and C) involved in the pathway leading to correctly folded beta-tubulin from folding intermediates. Cofactors A and D are believed to play a role in capturing and stabilizing beta-tubulin intermediates in a quasi-native confirmation. Cofactor E binds to the cofactor D/beta-tubulin complex; interaction with cofactor C then causes the release of beta-tubulin polypeptides that are committed to the native state. Two transcript variants encoding the same protein have been found for this gene.
Gene ID
6905
Gene Name (eCommerce)
tubulin folding cofactor E
Gene Name (Vector)
tubulin folding cofactor E
Gene Symbol
TBCE
HGNC ID
HGNC:11582
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1584
ORF Size (bp)
1584 bp
Protein Name (eCommerce)
Tubulin-specific chaperone E
RefSeq ID
NM_003193
RefSeq Synonyms
NM_003193, NM_001287802, NM_001287801, NM_001079515, BC008654,
Research Areas
Axonogenesis,Cytoskeleton,Metabolism/Metabolic Process,Neurobiology,Protein Folding,Translational Control
Research Areas (Faceted)
cell_biology,developmental_biology,metabolism,neurobiology,transcription_translation
Species
human
Target Sentence
Tubulin folding Cofactor E (TBCE) is one of four proteins (cofactors A, D, E, and C) involved in the pathway leading to correctly folded beta-tubulin from folding intermediates. Cofactors A and D are believed to play a role in capturing and stabilizing beta-tubulin intermediates in a quasi-native confirmation. Cofactor E binds to the cofactor D/beta-tubulin complex; interaction with cofactor C then causes the release of beta-tubulin polypeptides that are committed to the native stat.[taken from NCBI Entrez Gene (Gene ID: 6905)].
UniGene ID
Hs.498143
UniProt ID (eCommerce)
Q15813

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.