human TAF5 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human TAF5.
shAAV-224925
AAV-h-TAF5-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human TAF5 (TATA-box binding protein associated factor 5). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
TAF(II)100; TAF2D; TAF5 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 100kDa; TAFII100; TAFII-100; TATA box binding protein (TBP)-associated factor 2D; TATA box binding protein (TBP)-associated factor, RNA polymerase II, D, 100kD; transcription initiation factor TFIID 100 kD subunit; transcription initiation factor TFIID 100 kDa subunit; transcription initiation factor TFIID subunit 5
Description (eCommerce)
The TFIID complex is important for coordinating the pre-initiation complex and transcription by RNA Pol II. The complex contains the TFIID protein, TATA binding protein (TBP), and multiple TBP-associated factors (TAFs). TAF5 is an integral subunit of the transcriptionally competent TFIID complex.
Description (Vector)
Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes an integral subunit of TFIID associated with all transcriptionally competent forms of that complex. This subunit interacts strongly with two TFIID subunits that show similarity to histones H3 and H4, and it may participate in forming a nucleosome-like core in the TFIID complex.
Gene ID
6877
Gene Name (eCommerce)
TATA-box binding protein associated factor 5
Gene Name (Vector)
TATA-box binding protein associated factor 5
Gene Symbol
TAF5
HGNC ID
HGNC:11539
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2403
ORF Size (bp)
2403 bp
Protein Name (eCommerce)
Transcription initiation factor TFIID subunit 5
RefSeq ID
NM_006951
RefSeq Synonyms
NM_139052, NM_006951, BC136348, BC136340, BC052268,
Research Areas
Chromatin Remodeling,Cytoskeleton,Gene Expression,Histone Modification,Host-Virus Interactions,Transcription Factor/Regulator
Research Areas (Faceted)
transcription_translation,cell_biology,genetics,infectious_disease
Species
human
Target Sentence
The TFIID complex is important for coordinating the pre-initiation complex and transcription by RNA Pol II. The complex contains the TFIID protein, TATA binding protein (TBP), and multiple TBP-associated factors (TAFs). TAF5 is an integral subunit of the transcriptionally competent TFIID complex.
UniGene ID
Hs.96103
UniProt ID (eCommerce)
Q15542
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.