human SYN3 shRNA silencing AAV

Name
AAV-h-SYN3-shRNA

Cat No
shAAV-224806

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Human SYN3.

shAAV-224806

AAV-h-SYN3-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human SYN3 (synapsin III). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Description (Vector)

SYN3 is a member of the synapsin gene family. Synapsins encode neuronal phosphoproteins which associate with the cytoplasmic surface of synaptic vesicles. Family members are characterized by common protein domains, and they are implicated in synaptogenesis and the modulation of neurotransmitter release, suggesting a potential role in several neuropsychiatric diseases. The protein encoded by this gene shares the synapsin family domain model, with domains A, C, and E exhibiting the highest degree of conservation. The protein contains a unique domain J, located between domains C and E. Based on this gene's localization to 22q12.3, a possible schizophrenia susceptibility locus, and the established neurobiological roles of the synapsins, this family member may represent a candidate gene for schizophrenia. The TIMP3 gene is located within an intron of this gene and is transcribed in the opposite direction. Alternative splicing of this gene results in multiple splice variants that encode different isoforms.

Gene ID

8224

Gene Name (Vector)

synapsin III

Gene Symbol

SYN3

HGNC ID

HGNC:11496

ORF Size (aa)

1743

ORF Size (bp)

1743 bp

RefSeq ID

NM_003490

RefSeq Synonyms

NM_133633, NM_003490, NM_001135774, BC143874, BC117460, BC075066, BC075065,

Species

human

UniGene ID

Hs.608750

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.