human STK10 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human STK10.
shAAV-224573
AAV-h-STK10-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human STK10 (serine/threonine kinase 10). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
LOK; lymphocyte-oriented kinase; PRO2729; serine/threonine-protein kinase 10
Description (eCommerce)
LOK is a member of the Ste20 family of serine-threonine protein kinases. LOK associates with polo-like 1 kinase (PLK1) and may function to regulate its kinase activity. LOK has also been demonstrated to be involved in the regulation of the CD28 response-element in T-cells via the mitogen activated protein kinase kinase 1 pathway.
Description (Vector)
STK10 encodes a member of the Ste20 family of serine/threonine protein kinases, and is similar to several known polo-like kinase kinases. The protein can associate with and phosphorylate polo-like kinase 1, and overexpression of a kinase-dead version of the protein interferes with normal cell cycle progression. The kinase can also negatively regulate interleukin 2 expression in T-cells via the mitogen activated protein kinase kinase 1 pathway.
Gene ID
6793
Gene Name (eCommerce)
serine/threonine kinase 10
Gene Name (Vector)
serine/threonine kinase 10
Gene Symbol
STK10
HGNC ID
HGNC:11388
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2907
ORF Size (bp)
2907 bp
Protein Name (eCommerce)
Serine/threonine-protein kinase 10
RefSeq ID
NM_005990
RefSeq Synonyms
NM_005990, BC070077, BC014413,
Research Areas
Cell Cycle,Immunology,Kinase/Phosphatase
Research Areas (Faceted)
cell_biology,cell_cycle,genetics,immunology,signal_transduction
Species
human
Target Sentence
LOK is a member of the Ste20 family of serine-threonine protein kinases. LOK associates with polo-like 1 kinase (PLK1) and may function to regulate its kinase activity. LOK has also been demonstrated to be involved in the regulation of the CD28 response-element in T-cells via the mitogen activated protein kinase kinase 1 pathway.
UniGene ID
Hs.519756
UniProt ID (eCommerce)
O94804
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.