human STIM2 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human STIM2.
shAAV-224569
AAV-h-STIM2-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human STIM2 (stromal interaction molecule 2). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
stromal interaction molecule 2
Description (eCommerce)
STIM2 (stromal interaction molecule 2) plays a role in mediating store-operated Ca(2+) entry (SOCE), a Ca(2+) influx following depletion of intracellular Ca(2+) stores. Stim2 functions as a highly sensitive Ca(2+) sensor in the endoplasmic reticulum which activates both store-operated and store-independent Ca(2+)-influx. It regulates basal cytosolic and endoplasmic reticulum Ca(2+) concentrations. Upon mild variations of the endoplasmic reticulum Ca(2+) concentration, STIM2 translocates from the endoplasmic reticulum to the plasma membrane where it probably activates the Ca(2+) release-activated Ca(2+) (CRAC) channels ORAI1, ORAI2 and ORAI. STIM2 may inhibit STIM1-mediated Ca(2+) influx  [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q9P246].
Description (Vector)
STIM2 is a member of the stromal interaction molecule (STIM) family and likely arose, along with related family member STIM1, from a common ancestral gene. The encoded protein functions to regulate calcium concentrations in the cytosol and endoplasmic reticulum, and is involved in the activation of plasma membrane Orai Ca(2+) entry channels. STIM2 initiates translation from a non-AUG (UUG) start site. A signal peptide is cleaved from the resulting protein. Multiple transcript variants result from alternative splicing.
Gene ID
57620
Gene Name (eCommerce)
stromal interaction molecule 2
Gene Name (Vector)
stromal interaction molecule 2
Gene Symbol
STIM2
HGNC ID
HGNC:19205
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2526
ORF Size (bp)
2526 bp
Protein Name (eCommerce)
Stromal interaction molecule 2
RefSeq ID
NM_020860
RefSeq Synonyms
NM_020860, NM_001169118, NM_001169117, BC171766, BC152554, BC146661, BC136449,
Research Areas
Signal Transduction,Transport
Research Areas (Faceted)
signal_transduction,cell_biology
Species
human
Target Sentence
STIM2 (stromal interaction molecule 2) plays a role in mediating store-operated Ca(2+) entry (SOCE), a Ca(2+) influx following depletion of intracellular Ca(2+) stores. Stim2 functions as a highly sensitive Ca(2+) sensor in the endoplasmic reticulum which activates both store-operated and store-independent Ca(2+)-influx. It regulates basal cytosolic and endoplasmic reticulum Ca(2+) concentrations. Upon mild variations of the endoplasmic reticulum Ca(2+) concentration, STIM2 translocates from the endoplasmic reticulum to the plasma membrane where it probably activates the Ca(2+) release-activated Ca(2+) (CRAC) channels ORAI1, ORAI2 and ORAI. STIM2 may inhibit STIM1-mediated Ca(2+) influx  [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q9P246].
UniGene ID
Hs.135763
UniProt ID (eCommerce)
Q9P246
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.