human STIM1 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human STIM1.
shAAV-224566
AAV-h-STIM1-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human STIM1 (stromal interaction molecule 1). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
D11S4896E; GOK; IMD10; STRMK; stromal interaction molecule 1; TAM; TAM1
Description (eCommerce)
Stromal interaction molecule 1 (STIM1) a type 1 transmembrane protein that mediates Ca2+ influx after depletion of intracellular Ca2+ stores by gating of store-operated Ca2+ influx channels (SOCs). It is one of several genes located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocrotical carcinoma, and lung, ovarian, and breast cancer. This gene may play a role in malignancies and disease that involve this region, as well as early hematopoiesis, by mediating attachment to stromal cells [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/ Q13586].
Description (Vector)
STIM1 encodes a type 1 transmembrane protein that mediates Ca2+ influx after depletion of intracellular Ca2+ stores by gating of store-operated Ca2+ influx channels (SOCs). It is one of several genes located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocrotical carcinoma, and lung, ovarian, and breast cancer. STIM1 may play a role in malignancies and disease that involve this region, as well as early hematopoiesis, by mediating attachment to stromal cells. STIM1 is oriented in a head-to-tail configuration with the ribonucleotide reductase 1 gene (RRM1), with the 3' end of this gene situated 1.6 kb from the 5' end of the RRM1 gene.
Gene ID
6786
Gene Name (eCommerce)
stromal interaction molecule 1
Gene Name (Vector)
stromal interaction molecule 1
Gene Symbol
STIM1
HGNC ID
HGNC:11386
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2058
ORF Size (bp)
2058 bp
Protein Name (eCommerce)
Stromal interaction molecule 1
RefSeq ID
NM_003156
RefSeq Synonyms
NM_003156, NM_001277962, NM_001277961, BC021300,
Research Areas
B-cell Receptor Signaling,Cytoskeleton,Immunology,Signal Transduction,T-cell Receptor Signaling,Transport
Research Areas (Faceted)
signal_transduction,immunology,cell_biology,signal_transduction,immunology,cell_biology
Species
human
Target Sentence
Stromal interaction molecule 1 (STIM1) a type 1 transmembrane protein that mediates Ca2+ influx after depletion of intracellular Ca2+ stores by gating of store-operated Ca2+ influx channels (SOCs). It is one of several genes located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocrotical carcinoma, and lung, ovarian, and breast cancer. This gene may play a role in malignancies and disease that involve this region, as well as early hematopoiesis, by mediating attachment to stromal cells [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/ Q13586].
UniGene ID
Hs.501735
UniProt ID (eCommerce)
Q13586
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.