human ST3GAL5 shRNA silencing AAV

Name
AAV-h-ST3GAL5-shRNA

Cat No
shAAV-224461

Availability
4-5 weeks

This is an AAV expressing shRNA for silencing of Human ST3GAL5.

shAAV-224461

AAV-h-ST3GAL5-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human ST3GAL5 (ST3 beta-galactoside alpha-2,3-sialyltransferase 5). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

SATI; SIAT9; SIATGM3S; SPDRS; ST3GalV

Description (Vector)

Ganglioside GM3 is known to participate in the induction of cell differentiation, modulation of cell proliferation, maintenance of fibroblast morphology, signal transduction, and integrin-mediated cell adhesion. The protein encoded by this gene is a type II membrane protein which catalyzes the formation of GM3 using lactosylceramide as the substrate. The encoded protein is a member of glycosyltransferase family 29 and may be localized to the Golgi apparatus. Mutation in this gene has been associated with Amish infantile epilepsy syndrome. Transcript variants encoding different isoforms have been found for this gene.

Gene ID

8869

Gene Name (Vector)

ST3 beta-galactoside alpha-2,3-sialyltransferase 5

Gene Symbol

ST3GAL5

HGNC ID

HGNC:10872

ORF Size (aa)

1257

ORF Size (bp)

1257 bp

RefSeq ID

NM_003896

RefSeq Synonyms

NM_003896, NM_001042437, BC065936,

Species

human

UniGene ID

Hs.415117

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.