human ST3GAL1 shRNA silencing AAV

Name
AAV-h-ST3GAL1-shRNA

Cat No
shAAV-224457

Availability
4-5 weeks

This is an AAV expressing shRNA for silencing of Human ST3GAL1.

shAAV-224457

AAV-h-ST3GAL1-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human ST3GAL1 (ST3 beta-galactoside alpha-2,3-sialyltransferase 1). Available with optional GFP reporter or cell-specific promoter.

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Vector Designer

Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

1; Gal-NAc6S; SIAT4A; SIATFL; ST3GalA; ST3GalA.1; ST3GalIA; ST3O

Description (Vector)

ST3GAL1 is a type II membrane protein that catalyzes the transfer of sialic acid from CMP-sialic acid to galactose-containing substrates. The encoded protein is normally found in the Golgi but can be proteolytically processed to a soluble form. Correct glycosylation of the encoded protein may be critical to its sialyltransferase activity. This protein, which is a member of glycosyltransferase family 29, can use the same acceptor substrates as does sialyltransferase 4B. Two transcript variants encoding the same protein have been found for this gene. Other transcript variants may exist, but have not been fully characterized yet.

Gene ID

6482

Gene Name (Vector)

ST3 beta-galactoside alpha-2,3-sialyltransferase 1

Gene Symbol

ST3GAL1

HGNC ID

HGNC:10862

ORF Size (aa)

1023

RefSeq ID

NM_003033

RefSeq Synonyms

NM_173344, NM_003033, BC018357,

Species

human

UniGene ID

Hs.374257

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.