human SRPRB shRNA silencing AAV

Name 
AAV-h-SRPRB-shRNA
Cat No 
shAAV-224360
Availability
4-5 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human SRPRB.

shAAV-224360
AAV-h-SRPRB-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human SRPRB (SRP receptor beta subunit). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
90
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
APMCF1; Protein APMCF1; signal recognition particle receptor subunit beta; signal recognition particle receptor, B subunit; signal recognition particle receptor, beta subunit; SR-beta; SRP receptor beta subunit
Description (eCommerce)
Signal recognition particle receptor, B subunit (SRPRB) has similarity to mouse protein which is a subunit of the signal recognition particle receptor (SR). This subunit is a transmembrane GTPase belonging to the GTPase superfamily. It anchors alpha subunit, a peripheral membrane GTPase, to the ER membrane. SR is required for the cotranslational targeting of both secretory and membrane proteins to the ER membrane [taken from NCBI Entrez Gene (Gene ID: 58477)].
Description (Vector)
SRPRB has similarity to mouse protein which is a subunit of the signal recognition particle receptor (SR). This subunit is a transmembrane GTPase belonging to the GTPase superfamily. It anchors alpha subunit, a peripheral membrane GTPase, to the ER membrane. SR is required for the cotranslational targeting of both secretory and membrane proteins to the ER membrane.
Gene ID
58477
Gene Name (eCommerce)
SRP receptor subunit beta
Gene Name (Vector)
SRP receptor beta subunit
Gene Symbol
SRPRB
HGNC ID
HGNC:24085
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
816
Protein Name (eCommerce)
Signal recognition particle receptor subunit beta
RefSeq ID
NM_021203
RefSeq Synonyms
NM_021203, BC065299, BC063001,
Research Areas
Gene Expression,Immunology,Metabolism/Metabolic Process,Translational Control
Research Areas (Faceted)
cell_biology,immunology,metabolism,transcription_translation
Species
human
Target Sentence
Signal recognition particle receptor, B subunit (SRPRB) has similarity to mouse protein which is a subunit of the signal recognition particle receptor (SR). This subunit is a transmembrane GTPase belonging to the GTPase superfamily. It anchors alpha subunit, a peripheral membrane GTPase, to the ER membrane. SR is required for the cotranslational targeting of both secretory and membrane proteins to the ER membrane [taken from NCBI Entrez Gene (Gene ID: 58477)].
UniGene ID
Hs.12152
UniProt ID (eCommerce)
Q9Y5M8

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.