human SRP68 shRNA silencing AAV

Name 
AAV-h-SRP68-shRNA
Cat No 
shAAV-224342
Availability
4-5 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human SRP68.

shAAV-224342
AAV-h-SRP68-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human SRP68 (signal recognition particle 68). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
60
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
signal recognition particle 68 kDa protein; signal recognition particle 68kD; signal recognition particle 68kDa; signal recognition particle subunit SRP68; SRP68
Description (eCommerce)
Signal-recognition-particle assembly has a crucial role in targeting secretory proteins to the rough endoplasmic reticulum membrane. Signal recognition particle 68kDa (SRP68) binds the 7S RNA, SRP72 binds to this complex subsequently. This ribonucleoprotein complex might interact directly with the docking protein in the ER membrane and possibly participate in the elongation arrest function [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q9UHB9].
Description (Vector)
SRP68 encodes a subunit of the signal recognition particle (SRP). The SRP is a ribonucleoprotein complex that transports secreted and membrane proteins to the endoplasmic reticulum for processing. The complex includes a 7S RNA and six protein subunits. The encoded protein is the 68kDa component of the SRP, and forms a heterodimer with the 72kDa subunit that is required for SRP function. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and three pseudogenes of this gene are located within the Smith-Magenis syndrome region on chromosome 17.
Gene ID
6730
Gene Name (eCommerce)
signal recognition particle 68
Gene Name (Vector)
signal recognition particle 68
Gene Symbol
SRP68
HGNC ID
HGNC:11302
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1791
ORF Size (bp)
1791 bp
Protein Name (eCommerce)
Signal recognition particle subunit SRP68
RefSeq ID
NM_014230
RefSeq Synonyms
NM_014230, NM_001260503, NM_001260502, BC020238,
Research Areas
Gene Expression,Metabolism/Metabolic Process,RNA Binding,Translational Control
Research Areas (Faceted)
cell_biology,metabolism,transcription_translation
Species
human
Target Sentence
Signal-recognition-particle assembly has a crucial role in targeting secretory proteins to the rough endoplasmic reticulum membrane. Signal recognition particle 68kDa (SRP68) binds the 7S RNA, SRP72 binds to this complex subsequently. This ribonucleoprotein complex might interact directly with the docking protein in the ER membrane and possibly participate in the elongation arrest function [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q9UHB9].
UniGene ID
Hs.514495
UniProt ID (eCommerce)
Q9UHB9

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.