human SRGN shRNA silencing AAV

Name
AAV-h-SRGN-shRNA

Cat No
shAAV-224330

Availability
4-5 weeks

This is an AAV expressing shRNA for silencing of Human SRGN.

shAAV-224330

AAV-h-SRGN-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human SRGN (serglycin). Available with optional GFP reporter or cell-specific promoter.

Request a Quote

Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

PPG; PRG; PRG1

Description (Vector)

SRGN encodes a protein best known as a hematopoietic cell granule proteoglycan. Proteoglycans stored in the secretory granules of many hematopoietic cells also contain a protease-resistant peptide core, which may be important for neutralizing hydrolytic enzymes. This encoded protein was found to be associated with the macromolecular complex of granzymes and perforin, which may serve as a mediator of granule-mediated apoptosis. Two transcript variants, only one of them protein-coding, have been found for this gene.

Gene ID

5552

Gene Name (Vector)

serglycin

Gene Symbol

SRGN

HGNC ID

HGNC:9361

ORF Size (aa)

477

RefSeq ID

NM_002727

RefSeq Synonyms

NM_002727, NM_001321054, NM_001321053, BC015516,

Species

human

UniGene ID

Hs.1908

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.