human SPTLC2 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human SPTLC2.
shAAV-224295
AAV-h-SPTLC2-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human SPTLC2 (serine palmitoyltransferase long chain base subunit 2). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
hLCB2a; HSN1C; LCB2; LCB2A; NSAN1C; SPT2
Description (Vector)
SPTLC2 encodes a long chain base subunit of serine palmitoyltransferase. Serine palmitoyltransferase, which consists of two different subunits, is the key enzyme in sphingolipid biosynthesis. It catalyzes the pyridoxal-5-prime-phosphate-dependent condensation of L-serine and palmitoyl-CoA to 3-oxosphinganine. Mutations in this gene were identified in patients with hereditary sensory neuropathy type I.
Gene ID
9517
Gene Name (Vector)
serine palmitoyltransferase long chain base subunit 2
Gene Symbol
SPTLC2
HGNC ID
HGNC:11278
ORF Size (aa)
1689
ORF Size (bp)
1689 bp
RefSeq ID
NM_004863
RefSeq Synonyms
NM_004863, BC005123,
Species
human
UniGene ID
Hs.435661
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.